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Cetrimonium bromide
Cas No:57-09-0
Preservative; Emulsifier
l
2010-03-08

Cetrimonium bromide 也是陽離子界面活性劑,常見於潤髮乳.護髮霜等產品中

可安全用於漂洗產品,並且在免洗產品中濃度最高可達0.25%時可以安全使用。
CIR專家小組審查了表明口服從腸吸收不良的數據。
皮膚被吸但吸收不迅速。
這些季銨鹽對皮膚有刺激性和致敏性,對眼睛有刺激性。

儘管在誘導過程中觀察到刺激,但反復進行的濃度高達0.25%的侮辱性貼片試驗未產生致敏反應。

腹膜內註射35或10 mg / kg時,引起發育作用。
皮膚暴露於2%沒有產生髮育影響的證據,使用的所有誘變測定均為陰性。
在歐盟化妝品法規中列為烷基(C12-C22)三甲基溴化銨和氯化物。這些成分可以以最大濃度0.1%用作防腐劑。

https://cosmeticsinfo.org/ingredient/cetrimonium-bromide

2021-02-09

Cetrimonium Bromide, Cetrimonium Chloride, and Steartrimonium Chloride are quaternary ammonium salts used for a variety of purposes in cosmetics at concentrations of up to 10%. Cetrimonium Bromide given orally is poorly absorbed from the intestine and is excreted in feces. Cetrimonium Bromide applied dermally is absorbed into the skin, but not rapidly. Dermal irritation and sensitization and ocular irritation are seen with these quaternary ammonium salts. Cetrimonium Bromide was embryotoxic and teratogenic in mice following intraperitoneal injection of 35 mg/kg; only teratogenic effects were observed with 10 mg/kg. Embryotoxic effects consistent with maternal toxicity were seen in a rat-feeding study using 50 mg/kg/day. Dermal exposure to 2% Cetrimonium Chloride produced no evidence of teratogenieity; nor did 2.5% Steartrimonium Chloride. All mutagenesis assays used were negative. Repeated insult patch tests of concentrations of up to 0.25% Cetrimonium Chloride produced no sensitization reactions, although irritation was observed during induction. Based on the available data Cetrimonium Bromide, Cetrimonium Chloride, and Steartrimonium Chloride are considered safe for use in rinse-off cosmetic products but are safe only at concentrations of up to 0.25% in leave-on products.


https://journals.sagepub.com/doi/abs/10.1080/109158197227152

2022-04-02

根據現有數據,Cetrimonium Bromide、Cetrimonium Chloride 和 Steartrimonium Chloride 被認為可安全用於沖洗型化妝品,但僅在免洗型產品中濃度高達 0.25% 時才安全。

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