可安全用于漂洗产品，并且在免洗产品中浓度最高可达0.25％时可以安全使用。
CIR专家小组审查了表明口服从肠吸收不良的数据。
皮肤被吸但吸收不迅速。
这些季铵盐对皮肤有刺激性和致敏性，对眼睛有刺激性。
尽管在诱导过程中观察到刺激，但反復进行的浓度高达0.25％的侮辱性贴片试验未产生致敏反应。
腹膜内註射35或10 mg / kg时，引起发育作用。
皮肤暴露于2％没有产生髮育影响的证据，使用的所有诱变测定均为阴性。
在欧盟化妆品法规中列为烷基(C12-C22)三甲基溴化铵和氯化物。这些成分可以以最大浓度0.1％用作防腐剂。
https://cosmeticsinfo.org/ingredient/cetrimonium-bromide
Cetrimonium Bromide, Cetrimonium Chloride, and Steartrimonium Chloride are quaternary ammonium salts used for a variety of purposes in cosmetics at concentrations of up to 10%. Cetrimonium Bromide given orally is poorly absorbed from the intestine and is excreted in feces. Cetrimonium Bromide applied dermally is absorbed into the skin, but not rapidly. Dermal irritation and sensitization and ocular irritation are seen with these quaternary ammonium salts. Cetrimonium Bromide was embryotoxic and teratogenic in mice following intraperitoneal injection of 35 mg/kg; only teratogenic effects were observed with 10 mg/kg. Embryotoxic effects consistent with maternal toxicity were seen in a rat-feeding study using 50 mg/kg/day. Dermal exposure to 2% Cetrimonium Chloride produced no evidence of teratogenieity; nor did 2.5% Steartrimonium Chloride. All mutagenesis assays used were negative. Repeated insult patch tests of concentrations of up to 0.25% Cetrimonium Chloride produced no sensitization reactions, although irritation was observed during induction. Based on the available data Cetrimonium Bromide, Cetrimonium Chloride, and Steartrimonium Chloride are considered safe for use in rinse-off cosmetic products but are safe only at concentrations of up to 0.25% in leave-on products.
https://journals.sagepub.com/doi/abs/10.1080/109158197227152
根据现有数据，Cetrimonium Bromide、Cetrimonium Chloride 和 Steartrimonium Chloride 被认为可安全用于沖洗型化妆品，但仅在免洗型产品中浓度高达 0.25% 时才安全。